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Hypertension (83%) and renal impairment (27% with an eGFR 60 mL/min/1.73 m2) were prevalent co-morbid conditions

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Metabolite identities were confirmed based on inter self-built libraries and MetDNA ( The identity process settings of inter self-built libraries were as follows: 5 ppm error tolerance in precursor ion m/z and fragment ion spectra

[PMID: 29611550] PubMed record related to this compound for laboratory literature review

Interestingly, estrogen receptors ER and ER are located in the axons and synaptic terminals of pre-synaptic cells and also in the dendritic spines (structures crucial for synaptic transmission) of post-synaptic cells (McEwen and Milner, 2007), indicating a role in local regulation of synapsis instead of exerting an effect at nuclear transcription (Zarate et al., 2017)