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By stabilizing neuronal activity within these circuits, the medication reduces the hedonic pull toward sugary, salty, or highly processed foods
Lancet, 2026
When restarting semaglutide makes sense Restarting the same medication is usually the best choice if semaglutide worked well for you the first time (meaningful weight loss with tolerable side effects), if you stopped for reasons unrelated to the medication itself (cost, supply, scheduling), if your insurance or provider still covers semaglutide, and if you have no new medical contraindications
Some patients may remain at the 1.7 mg dose if the 2.4 mg dose is not tolerated
Vision loss, chronic headaches, and cognitive difficulties may all limit daily functioning
Routine labs and a focused clinical history often clarify the cause
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