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As an exploratory outcome, single doses of cotadutide led to dose-dependent improvement in glucose excursions post meals within 24 hours and food intake reduction from a single dose of 100 g

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Key techniques include: -HRMS (High-Resolution Mass Spectrometry) -LC-MS/MS (Liquid ChromatographyMass Spectrometry) -Peptide Mapping -Enzymatic Digestion (Trypsin, Glu-C, etc.) -1D & 2D NMR (COSY, HSQC) These orthogonal methods ensure complete structural confirmation

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This potential synergistic effect is particularly useful in studies that aim to understand the complex interactions of growth hormone secretagogues and their effects on various physiological parameters