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Certain medications such as antacids, analgesics, and antibiotics, infections, and even chronic illnesses can deplete glutathione levels in your body

A randomized controlled trial using a fractional factorial design showed that compared with placebo, the combined supplementation with riboflavin (3 mg/day) and niacin (40 mg/day) for five to six years reduced the prevalence of nuclear cataract but increased the progression of posterior subcapsular cataracts in population affected by multiple nutrient deficiency living in rural China (38)

PMID: 75

However, related research is still somewhat lacking, and we need more studies on its regulation of energy metabolism, lipid metabolism, and autophagy-related pathways under stress and non-stress conditions

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