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Diabetes & Metabolic Syndrome: Clinical Research & Reviews , 16(4), 987-994

Current clinical guidance supports their use for preconception health optimization

It's also used off-label in body composition optimization protocols where the goal is preserving muscle mass during intentional weight loss

Body Composition: Healthy participants experienced reductions in body fat percentage and tricipital skinfold ( p = 0.001), despite no changes in total body weight or body circumferences

Thats why positively affecting metabolic processes tends to have ripple effects across the body

While GLP-1 receptors are expressed in hypothalamic and reproductive pathways, human data do not demonstrate direct infertility effects