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[12] Published and anecdotal evidence further indicates that recreational consumption of kava beverages can often exceed these levels, surpassing the kavalactone doses used in clinical settings for the treatment of anxiety, which are aqueous extracts containing 140250 mg, taken once per day over six weeks, have demonstrated no significant toxicity

Gastroenterology 135 (4), 13111321

Sinha DK, Balasubramanian A, Tatem AJ, et al

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