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This is commonly referred to as a weight loss plateau
The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight
doi: 10.1111/dom.14280 33 DaviesMFrchLJeppesenOKPaksereshtAPedersenSDPerreaultLet al
Significant reductions (5% or more) usually manifest by month 3-4 with consistent dosing and adherence
Intensive weight loss intervention and cancer risk in adults with type 2 diabetes: analysis of the Look AHEAD randomized clinical trial
The key is maintaining consistency once you establish a new time to ensure stable therapeutic effects and adherence
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