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NICE recommends continuing GLP-1 therapy only if HbA1c reduces by 11 mmol/mol and weight decreases by 3% at 6 months for diabetes indications

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A significantly decreases GSH levels in MC65 nerve cells, increases nonenzymatic and enzymatic oxidation of arachidonic acid (COX, 5-LOX, 12-LOX, and 15-LOX), and increases mitochondrial ROS levels and total intracellular lipid peroxides

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Clinical Trials on GLP-1 Single Agonists Liraglutide: The First GLP-1RA Approved for Adolescent Obesity Liraglutide (Saxenda ) was the first glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for the management of obesity in adolescent populations