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According to the POLAR study, intravenous administration of calmangafodipir and oxaliplatin was too close in time, which may lead to unfavorable redox interactions between Mn2 + and Pt 2 , while administration of calmangafodipir 10 min before the start of oxaliplatin infusion in previous mouse studies as well as in a phase II clinical trial (PLIANT) could avoid destructive interactions between calmangafodipir and oxaliplatin [158]
PMID: 28797793
In contrast, CB-839 showed no antitumor activity in PDAC mouse models due to the use of alternative metabolic pathways (e.g., fatty acid and lipid metabolism) by these cancer cells 45
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