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However, it is essential to distinguish between the drug's direct effect and the physiological stress of rapid weight loss, which can temporarily fluctuate hormonal profiles

In MS, GSH metabolism is impaired in regions of the CNS that have been demyelinated and correlates with mitochondrial dysfunction and axonal injury (Ferreira et al., 2013)

Expecting significant weight loss within the first few days or weeks

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The primary outcome measure for the SELECT trial is the incidence of three-point MACE