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In this study, however, one-third of the involved population remained with the starting dose of 3 mg despite the recommendation reported in the summary of product characteristics and only 16% reached the maintenance dose of 14 mg [28]

6.1.2 NLRP3 inflammasome inhibitors The NLRP3 inflammasome is a multiprotein complex that becomes activated following ischemic stroke, promoting the maturation and release of IL-1 and IL-18, thereby exacerbating neuroinflammation (221)