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This mechanism is critical because neurons have a limited ability to synthesize endogenous GS (Dringen and Arend, 2025)
doi: 10.3389/fimmu.2025.1610368 Received 11 April 2025 Accepted 26 June 2025 Published 15 July 2025 Volume 16 - 2025 Edited by Li-Tung Huang, Kaohsiung Chang Gung Memorial Hospital, Taiwan Reviewed by Beata Kasztelan-Szczerbinska, Medical University of Lublin, Poland Edit Posta, University of Debrecen, Hungary Updates Copyright 2025 Migliorisi, Gabbiadini, Dal Buono, Ferraris, Privitera, Petronio, Bertoli, Bezzio and Armuzzi
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By the 5th week, it can be increased to 5 mg weekly for another 4-week period
DOI:10.1056/NEJMoa1603827
It follows a ping-pong mechanism
