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Therefore, drugs with a potent antihyperglycemic effect, independent of the glomerular filtration rate, with a low risk of hypoglycemia, that reduce weight in overweight/obese patients and that provide cardiovascular and renal protection, such as GLP-1 receptor agonists, are needed
In 1992, a proof-of-concept study first suggested the potential of GLP-1 as an anti-diabetes drug, as a 3-hour continuous intravenous GLP-1 infusion significantly lowered the meal-related insulin requirement in patients with diabetes
These drugs are commonly prescribed for weight management, to treat type 2 diabetes, or to reduce the risk of heart attacks and stroke in people with cardiovascular disease
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