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In November 2025, the Trump administration announced it had negotiated a significant price drop for Medicare and Medicaid enrollees
The key variables in this analysis: what percentage of your total pharmacy spend is on generic drugs (typically 85-90% of prescription volume but only 20-30% of total drug spend), what percentage of those generics are classified as specialty by your current PBM (and thus dispensed through PBM-affiliated specialty pharmacies at inflated margins), and what is the spread between your current contracted price and Cost Plus acquisition cost for those drugs
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Zepbound should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)
Targeting the GIPR for obesity: To agonize or antagonize
Lab testing is not required to enroll
