Indeed, by the mid-1990s, Eng was desperate
Suppression of angiotensin II-activated NOX4/NADPH oxidase and mitochondrial dysfunction by preserving glucagon-like peptide-1 attenuates myocardial fibrosis and hypertension
During clinical trials for those conditions, researchers noticed an interesting side effect: patients kept losing weight
Arentz S, Smith CA, Abbott J, Bensoussan A
Likewise, the mechanism behind the apparent decreases in glutathione following placebo seen in Fig 1 remain uncertain (though a similar trend has been seen in other studies [25])
A meta-analysis of 8 RCTs found that NAC supplementation significantly reduced fasting glucose (WMD: -5.84 mg/dL) and HbA1c (WMD: -0.27%) in people with metabolic conditions (Sarkaki et al., Clin Nutr ESPEN, 2021) [57]