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everything else is uncontrolled No approval process underway : no sponsor has pursued formal approval Quality concerns : peptide impurities and characterization challenges in unregulated manufacturing The economic reality: Unpatentable peptides cannot justify the $50100M+ investment required for Phase 3 clinical trials, which is why BPC-157 has peer-reviewed preclinical data and one underpowered controlled trial rather than a development programme
The retraction is permanent and the paper should no longer be cited as evidence for the HGF/c-Met mechanism, although the underlying mechanism has been corroborated in subsequent independent work (e.g., Sun et al
A 2015 paper on GHK as a natural modulator of skin-regeneration pathways similarly maps multiple cellular pathways, again in models rather than large human trials (PMC4508379)
This therapy boosts collagen production and tissue repair
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