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High-risk groups include older adults, vegans, individuals with pernicious anaemia, those with malabsorption conditions such as Crohn's disease or coeliac disease, people taking metformin or proton pump inhibitors long-term, and those with recent nitrous oxide exposure including recreational use

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AOD-9604 is a synthetic fragment of the C-terminal region of human growth hormone (amino acids 177-191)

People with cancer (active or suspected): As mentioned previously, TB4 and TB-500 can promote the growth of new blood vessels, which could support the growth or spread of cancer.36 Professional athletes: TB4 and TB-500 are banned by the World Anti-Doping Agency (WADA)

10.1089/scd.2017.0251 95 NaziruddinB.IwahashiS.KanakM