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Glucagon-like peptide-1 receptor gene polymorphism (Leu260Phe) is associated with morning cortisol in preschoolers

Demonstrating the presence of the ghrelin peptide centrally has remained difficult, and hence no definite ligand for GHSR1a has been identified in many areas of the brain

In contrast, M-CuP showed negligible binding to either target, with maximal responses below 5 response units (RU) across all tested concentrations, confirming the essential role of multivalent architecture in cooperative target engagement