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In animal models, retatrutide reduced food intake , body weight , and glycemic markers more than GLP-1 monotherapy and dual GLP-1/GIP agonists

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These are pharmaceutical-grade results backed by massive randomized controlled trials involving thousands of participants

doi: 10.1111/1753-0407.12198 172 RosenstockJSorliCHTrautmannMEMoralesCWendischUDaileyGet al

Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

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