This hypertrophic shift recapitulates features of endochondral ossification and contributes to cartilage calcification, tidemark duplication, and eventual osteophyte formation at joint margins (Rim et al., 2020)
In cancer treatment, some widely used chemotherapeutic drugs (such as cisplatin, doxorubicin, arsenic trioxide (As 2 O 3 ), paclitaxel) enhance the apoptosis of cancer cells by inducing the production of intracellular ROS, prompting tumor cells to lose their ability to survive in an oxidative stress environment [466, 467]
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Concentration used: Higher concentration products may produce faster visible results, though the ceiling effect means 3% does not work three times faster than 1%
The lower dose (22.5mg or 150mg/L concentration) in this study did not produce a response