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Fifty-two weeks of treatment with the once-weekly dual GIPR/GLP-1R agonist tirzepatide has been demonstrated to reduce liver fat content and improve liver enzyme levels compared with insulin degludec

References (1) Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C

Digestive enzymes are proteins made in the stomach, small intestine, and pancreas that break down food and help digestion

Moreover, mitochondria-targeted antioxidant Mito-Tempo alleviates diabetic tubular injury and TECs apoptosis by reducing mitochondrial double-stranded RNA release and inhibiting the activation of the PKR/eIF2 signaling pathway (109), indicating that mitochondria quality control dysfunction is a significant upstreaming point in regulating apoptosis

Second, increased exposure to GLP-1RA, especially over extended durations, accentuated this protective association with a duration-response pattern

Add minoxidil at a different time of day