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The UK product information notes that semaglutide caused C-cell tumours in rodents (though the human relevance is uncertain) and advises monitoring for thyroid symptoms, especially with pre-existing thyroid disease
doi: 10.1111/bjh.18287 76 ZecherDCumpelikASchifferliJA
The lysosomal destabilization and cathepsin B release to the cytosol has been confirmed in a murine in vivo model as well as in human MASLD (Feldstein et al
doi: 10.1002/vms3.684 451 MandrichLEspositoAVCostaSCaputoE
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J Translational Med
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