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With the knowledge that UF is hormone-dependent, pharmacological agents that target the hormonal pathways, such as gonadotropin-releasing hormone (GnRH) agonist, selective progesterone receptor modulator (SPRM), and aromatase inhibitor, have been developed as a treatment choice for UF

In general, topical medications (such as creams or ointments) are going to have much less systemic absorption, and typically have little impact on male fertility potential

These agents target upstream cytokines, offering longer dosing intervals and sustained remission even after discontinuation (K

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The main adverse reactions were gastrointestinal side effects, including nausea, diarrhea, and vomiting