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Resistance exercise stimulates muscle protein synthesis and provides a protective stimulus against muscle breakdown during caloric restriction

Research Summary Obesity Phase 2 Phase 2 Complete Phase 2 trial (n=338, non-diabetic obesity): 24-week dose escalation to 12 mg produced 17.5% weight reduction at 24 weeks, extrapolating to estimated 24% at 48 weeks

In vitro, in differentiated human DA neurons, IR was associated with increased -synuclein and ROS levels, as well as mitochondrial depolarization, which may be mediated by polo-like kinase-2

Overall, GLP-1RAs and SGLT-2is not only share a common central nervous mechanism but also have an individual neuronal pathway, which are mutually complementary, and play a crucial role in effectively treating T2D patients