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Oxaliplatin-Induced Cold Hypersensitivity Is Due to Remodelling of Ion Channel Expression in Nociceptors

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The authors found that variations in Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), the gene responsible for Nrf2, in lung transplant recipients resulted in an increased susceptibility to PGD due to a reduction in transcription of ROS detoxifying enzymes and the attenuation of the resultant oxidant stress response

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Overall, the purpose of combining ML and Bayesian components is to improve transparency and updatability, supporting shared decision-making under heterogeneity and incomplete evidence, while avoiding spurious over-precision in reported risks or benefits (173)

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Reports of severe VHT following acute VPA overdose are rare [50]

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