glutathione nausea Injections: Side Effects & Benefits 🥇 Is Glutathione Good for

2000;130(5S Suppl):1399S-S1406

E N D Presentation Transcript PHASE II DRUG METABOLISM: Glucuronidation and Sulfation General properties of Phase II metabolism Introduction to glucuronidation Substrates for UGTs UGT structure Properties of glucuronides Methods to characterize glucuronides Disposition and reactions of glucuronides UGT pharmacogenetics, polymorphism, variability Sulfotransferases N-Acetylation, Aminoacid conjugation, Glutathione conjugation Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Recommended Reading: Gonzales and Tukey, Drug Metabolism, In: Goodman and Gilmans, The Pharmacological Basis of Therapeutics, 11th Edition, 2005, Chapter 3

Glutathione Supplementation Summary Oral powder (not recommended) Liposomal glutathione formulation (recommended) Inhaled GSH with a special nebulizer (recommended but need a prescription) Transdermal and lotions (variable levels of absorption) IV (most effective but also most invasive) Boost levels with selenium, ALA, NAC, and/or SAMe (recommended) Glutathione supplementation has a few rare side effects, including abdominal cramps, bloating, loose stools, gas, and possible allergic reactions such as rash

These tend to occur early in treatment and often resolve as the body adjusts

Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation

You will answer a few questions about symptoms to help us prepare for your visit prior to scheduling your appointment