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CVD includes heart disease, heart failure, stroke, and peripheral arterial disease

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In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]

Others are taken daily by injection, such as Victoza, Saxenda, and Byetta, or as a daily oral tablet, such as Rybelsus

and Mitchell, J.R

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