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[13] [14] UK SmPCs for licensed GLP-1 receptor agonists do not list medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) as formal contraindications, but advise vigilance for symptoms such as a neck lump, hoarseness, or difficulty swallowing

Liraglutide mimics the naturally produced hormone called GLP-1 (glucagon like peptide-1), which is produced by the lining of the intestines

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But the exact mechanism by which this therapeutic effect sometimes becomes a pathological one, where delayed emptying crosses the line into permanent gastroparesis, remains unclear

In fact, with the exception of the lowest treatment dose investigated (2.5 mg oral semaglutide), almost 100% of patients experienced a reduction in HbA 1c in the phase II trial, indicating that the variability in semaglutide exposure is not likely to affect the proportion of subjects with a clinically relevant treatment response [10]