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Exposure to extreme temperatures can negatively impact the medications effectiveness and safety

however, during the open-label follow-up, delayed risk reductions of 15% for myocardial infarction (p=0.01) and 13% for all-cause mortality (p=0.007) were observed

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Nausea tops the list, often accompanied by acid reflux, constipation or diarrhea, and occasional vomiting or abdominal pain (Health.com)

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