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Metformin facilitates the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells in vitro

Can diet alone improve glutathione levels

Amanda Gesselman, Research Scientist at the Kinsey Institute and one of the studys authors

Dysfunction of System Xc , depletion of GSH, or inhibition of GPX4 activity can lead to the accumulation of iron-dependent lipid peroxides, ultimately initiating ferroptosis (Guo et al., 2025a)

Early clinical trials also showed some risk, so patients with a history of acute pancreatitis were excluded from subsequent trials, and the FDA issued a warning in respect of pancreatitis risk in 2007

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