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Here is a non-exhaustive list of tirzepatide side effects observed to date [7, 10, 11, 12, 13, 14]: Nausea Vomiting Diarrhea Reduced appetite Constipation Indigestion Dyspepsia Abdominal pain Hypersensitivity reactions Researchers should note that tirzepartide has a gastric emptying effect, and are therefore advised to refrain administering the peptide to subjects with severe gastrointestinal disease [22]