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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12
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Unit measurements at 7.5mg: 5mg/ml: 150 units (requires two injections) 10mg/ml: 75 units 20mg/ml: 37.5 units 40mg/ml: 18.75 units This dose level is where concentration choice starts to matter practically
The native parent is a much larger (~40-kDa) protein present in human gastric juice
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