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The REDEFINE 1 Phase 3 trial extended this observation, showing 11.8% weight loss with cagrilintide 2.4 mg alone over 68 weeks

The ghrelin/GHRP system modulates pulse timing and frequency by acting at both hypothalamic (stimulating GHRH neurons, inhibiting somatostatin neurons) and pituitary (direct somatotroph stimulation) levels

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It is specifically known for its ability to reduce excess abdominal fat (visceral adipose tissue) in individuals with HIV-associated lipodystrophy, but it is also researched for other potential metabolic and cognitive benefits

Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia

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