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Giovagnoli1 1Department of Pharmaceutical Science, University of Perugia, Perugia, 06123, Italy 2Department of Medicine and Surgery, University of Perugia, Perugia, 06132, Italy 3Macquarie Medical School, Faculty of Medicine, Health, and Human Sciences, Macquarie University, Sydney, NSW 2109, & The Woolcock Institute of Medical Research, Sydney, NSW, 2031, Australia Summary: Due to mechanical, chemical and immunological barriers to the respiratory tract, pulmonary drug delivery is complex and demands strategies and formulations that maximize airway selectivity