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[2] It is important to note that whilst fatigue and general malaise may improve relatively quickly, complete symptom resolution requires adequate time for the body to replenish B12 stores and repair affected tissues

That means your body can draw from these stores for years before you start to show signs of a deficiency

Additionally, a study that administered vitamin B-12 to rats with a high-fat diet showed that the rats did not gain as much weight as their counterparts who didnt receive the vitamin

Johansson JO, et al

Allow the initial dose to establish baseline response before making adjustments

What exists in the scientific literature