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Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16

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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

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Gnoni, A., Longo, S., Gnoni, G