Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]
Acknowledgements We would like to acknowledge the use of pictures from Servier Medical Art, by Servier ( Financial support The review was supported by The Biomedical Indicators for Personalized Medicine project (BIPOLE), project ID CZ.02.01.01/00/23_021/0008439, co-funded by the European Union
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also identified as G6PDH)
Acta Pediatr Scand 74 , 500504
Cisplatin and carboplatin, two platinum-based chemotherapeutic agents, have similar efficacy profiles, with carboplatin exhibiting reduced toxicity compared with cisplatin