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A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study
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These numbers exceed what semaglutide achieves alone and compete favorably with surgical interventions
Animal studies have shown that GLP-1 receptors are present on bone cells, including osteoblasts and osteoclasts, suggesting a potential direct effect on bone metabolism, though the clinical relevance in humans remains uncertain
