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Poston says

There is currently no satisfactory explanation for this, and the lack of effects of sodium channel blockers (which prevent action potentials) on glucagon secretion also contradicts this

Management: This is typically dose-related

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One published case series (N=14 patients, mixed athletic backgrounds) noted that 11 of 14 participants reported reduced DOMS duration from an average of 72 hours to approximately 36 hours, though this was self-reported and uncontrolled

Background investigations may ask about substance use beyond what appears on a drug test