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The insula, for example, is reliably activated during threat anticipation (Sambuco, Costa, et al., 2020b, 2020a) but less so during free viewing of emotional images, where inferior frontal gyrus (IFG) activation near opercular regions may be the primary driver (Sambuco, Bradley, et al., 2020), and spatial smoothing could misattribute these effects to the adjacent insula

It cannot be marketed or sold as a supplement or over the counter treatment

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However, at present, studies are predominantly limited to small animal models (predominantly rodents) and the efficacy of BPC 157 is yet to be confirmed in human subjects

It also increases cardiovascular risks

J Psych Res