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Abstract Aims/hypothesis There is a growing need for markers that could help indicate the decline in beta cell function and recognise the need and efficacy of intervention in type 1 diabetes

Under oxidative stress, KEAP1 modifications release NRF2, enabling its nuclear translocation to activate antioxidant genes

Multiple Ya subunits of glutathione S-transferase detected by monoclonal antibodies

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GSH is synthesized in vivo, by the consecutive action of two ATP-dependent enzymes, from the precursor amino acids cysteine, glutamate and glycine