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I closely follow the ones that are abnormal

These data suggest that in the absence of GSH synthesis, the liver accumulates GSH precursors and can re-route them into alternative metabolic pathways

As erastin decreases host GSH levels, we tested the impact of increasing concentrations of erastin on the inducible GR -KO line

we also determined whether the possible underlying mechanisms of its effects were associated with Nrf2-regulated anti-oxidative, mTOR-mediated anti-apoptotic, and/or autophagy systems

doi: 10.12944/CRNFSJ.11.3.21 65 MoraI.Prez-SantamariaA.Tortajada-PrezJ.Vzquez-ManriqueR

J Appl Physiol 99(5):20082019