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However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans
Most people see a 50% or greater reduction within 3 to 5 days of strict elimination
None of the other pooled adverse pregnancy outcomes reached statistical significance, although several estimates remained imprecise
A study that enrolled over 4000 participants reported that for every 1 mg/dL increase in vitamin C in the serum, there was a 26% decrease in cataracts (Simon 1999)
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[cited 2023 June 22] 11
