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Diary cards were provided to participants on days 1, 7, 14, and 21, onto which participants were instructed to record their temperature, adverse events (AEs), medication, and supplementation

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For Cagri:AMY 3 R:G s , histidine side chains were predicted in the tautomeric state except H223, H302 (CTR), H18 (Cagri), H97 (RAMP3), H142, and H183 (G), which were modelled as tautomer