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Historically, the management of T2D in people with hepatic impairment was complicated by the propensity of small-molecule anti-hyperglycemia medications to rely on the liver organ system for metabolism and subsequent elimination

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J Dental Res 89:219229 Guo Y, Lin C, Xu P (2016) AGEs induced autophagy impairs cutaneous wound healing via stimulating macrophage polarization to M1 in diabetes

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Headaches or Fatigue Some individuals experience headaches or mild fatigue while adjusting to the medication