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The back-to-back arguments on tirzepatide, the active ingredient in Eli Lillys Mounjaro and Zepbound, and the related semaglutide case, Novo Nordisks Ozempic and Wegovy, boiled down to two questions: Did the FDA follow the right procedure, and did it actually look at the facts fairly

No significant difference in diastolic BP was observed between semaglutide and the comparators

Deficiencies in these nutrients can occur due to disease, poor diet, and/or a genetic mutation on the MTHFR gene

In contrast, individuals with SIRD who were dysregulated at randomization had presented with already high HOMA2-IR at diagnosis and showed a marked decrease in HOMA2-B between diagnosis and study inclusion, indicating that metformin treatment had been insufficient

This creates a devastating feedback loop: mast cells release histamine, which causes systemic inflammation