Indeed, in the cardiovascular outcome trial (CVOT) for semaglutide, SUSTAIN 6 a relatively short (two-year) and small (3,297 individuals) preregistration trial (an extensive CVOT in obese individuals without T2DM (SELECT) is expected to complete in 2024) HbA 1c was powerfully and durably reduced
In my previous Substack posts, we've unpacked the transformative power of GLP-1 medicationshow they work, why they're so effective against obesity, and how physicians like myself carefully use them off-label to tackle metabolic dysfunction at its core
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therefore, we further investigated whether the cytoprotective effects of Exe and PPAR are associated with mitochondrial function
Vision loss is just one of the many consequences