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The interaction does not prevent using these medications together, but it may require levothyroxine dose adjustments as T4 levels may run higher than expected

Conversely, antagonizing amylin receptors leads to an increase in adipose tissue [95]

A 2025 preprint showed semaglutide users were about 50% more likely to receive a hair-loss diagnosis than users of Contrave again pointing to an indirect mechanism

Lin SH, Hobbs BP, Verma V, Tidwell RS, Smith GL, Lei X, Corsini EM, Mok I, Wei X, Yao L, Wang X, Komaki RU, Chang JY, Chun SG, Jeter MD, Swisher SG , Ajani JA, Blum-Murphy M, Vaporciyan AA, Mehran RJ, Koong AC, Gandhi SJ, Hofstetter WL, Hong TS, Delaney TF, Liao Z, Mohan R

00:10:48 Vickie Danaher In terms of serious safety concerns, orforglipron carries the same precautions and warnings as other GLP-1 agonists, so rare risks of thyroid tumors, pancreatitis, and gallbladder disease, for example

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