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This depends on several things

The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

If a significant part of this mechanism relies on re-absorption from bile that would be an issue due to lack of intrinsic factor breaking the "enterohepatic recirculation"

Adequate levels of vitamin B12 are also required for a healthy nervous system, pregnancy, and the ability to produce DNA

There is one piece of patient counseling that matters more than any protocol detail