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Vitamin B12 is also involved in homocysteine metabolism and is critical in proper energy metabolism, immune function, and nerve function

(3) In naturally aged mice, FOXO4-DRI treatment reduced senescent cell burden, improved liver and kidney function, restored exercise tolerance (grip strength and running capacity), and improved coat appearanceall markers of healthier aging

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As a peptide derived from human gastric juice, it is natively resistant to low pH and proteolytic enzymes

FOXO4-DRI is a senolytic peptide that targets p53, a crucial tumor suppressor that prevents genomic mutations 34

This step is catalyzed by the lipoic acid synthetase (also called lipoyl synthase), an enzyme containing iron-sulfur clusters that act as sulfur donors in the reaction (5)